The right-hander gets a chance to avenge that performance as he tries to help the Angels complete a three-game home sweep of the Twins on Wednesday night.
After allowing four hits and striking out 10 in eight innings of a season-opening 5-0 victory over Kansas City on April 6, Weaver (3-0, 2.02 ERA) gave up five runs and seven hits in six-plus innings of a 6-5 loss at Minnesota on April 11.
Weaver is 5-2 with a 4.19 ERA in 11 starts against Twins. He has a 4.45 ERA in five home starts against them, but is 4-0 in those contests.
However, since that rough outing at Minnesota, Weaver has allowed three runs over 21 2-3 innings while going 2-0 in three starts. He scattered seven hits and a season-high four walks in six scoreless innings Friday, but the Angels' bullpen failed to hold a 2-0 lead in an eventual 3-2 defeat at Cleveland.
"Jered wasn't as crisp as we have seen earlier in some of his starts," manager Mike Scioscia told the Angels' official website. "He wasn't as dialed in, but that's just how good Jered is."
After journeyman Jerome Williams pitched a three-hitter in Tuesday's 4-0 win over Minnesota, Weaver looks to help Los Angeles (9-15) complete its first home sweep of the Twins since Aug. 10-12, 2007.
The Angels, however, have yet to win three straight games in 2012.
Though Albert Pujols went 0 for 4 and began May the same way he went through April - without a home run - Torii Hunter homered and drove in two runs Tuesday. The ex-Twin, who has four homers in five games, is batting .477 (21 for 44) with three homers and 11 RBIs during a 12-game hitting streak against his former team.
Pujols, meanwhile, is batting .208 in 2012 and has gone 125 regular-season at-bats since last homering Sept. 22, 2011.
Denard Span had two of the three hits for Minnesota (6-17), which has lost eight of nine. The center fielder has been one of the few bright spots for the Twins, batting .340 this season and in the midst of a career-high 12-game hitting streak.
Span, however, is 2 for 15 with seven strikeouts against Weaver.
Justin Morneau is expected to rejoin the Twins on Wednesday, but it's likely he will miss his second straight game after flying back to Minnesota to undergo an MRI on his injured left wrist - the same one he had surgery on during the offseason.
"He got some peace of mind knowing that he hasn't re-injured the tendon or that there was not anything structural with the wrist, so this is something he can deal with," manager Ron Gardenhire told the Giants' official website.
Still looking for his first major league win, Minnesota's Liam Hendriks (0-1, 6.89) makes his first appearance against the Angels.
The right-hander has taken a step back in each of his last two starts after allowing one run in six innings of a 4-3 loss to Texas in his season debut April 15. Hendriks was tagged for seven runs and nine hits in four innings of a 7-6 loss to Boston last Wednesday.
He is 0-3 with a 6.46 ERA in seven career starts dating to last season.