Santana goes 7 innings, Royals top Sox 4-2
The nightcap was scheduled after Friday night's game was postponed because of the manhunt for a suspect in the Boston Marathon bombings.
Santana (2-1) allowed two runs on six hits with no walks and seven strikeouts. It was the third straight start in which he gave up two runs or less.
The Red Sox loaded the bases with two outs in the eighth against Bruce Chen and Aaron Crow, but Jarrod Saltalamacchia grounded out to Crow. Greg Holland pitched a perfect ninth for his fourth save in five opportunities.