Both starters Thursday will be aiming to turn around some significant woes when the Yankees and Rangers complete this three-game set.
Hughes (3-6, 5.09 ERA) has posted a 13.91 ERA in losing three straight starts at Yankee Stadium for the first time. He surrendered five runs over six innings in last Wednesday's 6-0 loss to the Dodgers in the second game of a doubleheader.
With Ivan Nova turning in a solid effort Sunday in his return for New York (42-35), there could be more pressure on Hughes to remain in the rotation although manager Joe Girardi hasn't indicated that he will make such a decision yet.
"My only concern is pitching well," Hughes told the Yankees' official website. "Things that I can't control, I don't really concern myself with."
Hughes is 0-3 with a 11.91 ERA in his last three starts against the Rangers, including two in the 2010 postseason. He has never started against Texas at home.
It's hard to give either team an edge in the mound matchup Thursday, however, since Holland (5-4, 3.43) is 0-5 with an 8.69 ERA in seven career starts against the Yankees, including 0-3 with a 7.77 ERA in four in the Bronx.
"I know New York has been pretty tough (for me), but my job is not to worry about that," Holland told the Rangers' official website. "I need to turn the page and make something else happen."
Making matters worse for Texas (45-33) is that New York is 15-9 against left-handed starters for baseball's second-best mark behind the Rangers' 16-9 record.
Holland is 0-2 with a 5.40 ERA in his last four starts, yielding four runs and four hits in seven innings in a 6-4 victory at St. Louis.
The Yankees hitter he has faced the most is Ichiro Suzuki, who is 9 for 33 against him and has homered in each of the first two games of this series while going 5 for 9.
Texas won for just the third time in its last 15 regular-season games at New York with Wednesday's 8-5 victory. Nelson Cruz homered and Adrian Beltre and A.J. Pierzynski had consecutive two-run doubles.
"What was nice was to see the middle of my order come up big," manager Ron Washington said. "We need that. Without those guys doing what they did and what they are capable of doing, it would be a long year. They pulled it out for us tonight."
The defeat capped a difficult day for the Yankees, who announced that Mark Teixeira would be lost to season-ending wrist surgery. Lyle Overbay, hitting .239 with eight homers, figures to continue to fill in at first base.
"It doesn't really change what we're trying to accomplish, it just makes it a little bit different in how you accomplish it," Girardi said.
More pressure will be placed on Robinson Cano, who has six singles in 22 at-bats along with eight walks on this homestand while enduring a season-high 11-game homerless drought.