The rest of the San Diego Padres' lineup also really enjoyed their latest visit to the storied ballpark.
Quentin looks to continue his success against the Cubs as the Padres attempt to build upon their best offensive display of the season Wednesday night.
The two-time All-Star has a .337 average with nine homers and 26 RBIs in 29 career meetings with Chicago. Quentin has been especially dangerous versus the Cubs since the Padres acquired him from the White Sox prior to last season, batting .480 with five homers and 12 RBIs in seven games.
Much of that damage has come on the North Side, where he's 10 for 19 with five doubles, four homers and nine RBIs over the past five visits. His .344 career average at Wrigley is his highest at any ballpark.
Quentin was at it again there Tuesday, connecting for two doubles and a solo homer while driving in three runs in a 13-7 victory. It was the first time this season the Padres scored in double figures, and every member of the lineup had at least one of their season-high 17 hits.
San Diego (10-16) had nine extra-base hits in that win after getting only one in a 5-3 loss to open this four-game set Monday, ending a four-game winning streak.
Andrew Cashner (1-1, 3.26 ERA) is scheduled to take the mound, and he's rather familiar with Wrigley Field.
The right-hander went 2-6 with a 4.29 ERA while making 59 of 60 appearances out of the bullpen for Chicago from 2010-11. A first-round pick in 2008, Cashner was sent to San Diego in a deal that delivered Anthony Rizzo to the Cubs (10-16).
"My first start with the Padres (at Wrigley), but it's just another game," Cashner told the team's official website. "You don't treat it any different. You don't get too up or too down. You try to just stay the same every start you make."
Cashner faced the Cubs twice in relief last season - both in Chicago - and allowed two runs in two innings.
He enters this visit following his first win in eight career starts, yielding one run in six innings of a 2-1 victory over San Francisco on Friday.
"I think in the last two years I've polished my changeup," Cashner said. "My breaking ball is getting better and I found my changeup later in the game. Everything is finally coming together."
Cashner will be facing a hot-hitting Rizzo, who doubled on all three of his hits and drove in one run Tuesday. The first baseman is 8 for 17 with four doubles, two homers and six RBIs over the last five games. He's struck out in his only at-bat versus Cashner.
Scott Feldman (1-3, 3.92) is slated to get the ball coming off his first win with Chicago, allowing two runs in 6 2-3 innings of a 4-2 victory at Miami on Friday. The right-hander had given up 14 runs - seven earned - in 14 innings through his first three starts.
He was credited with a 7-3 win in his only start versus San Diego on June 19, yielding two runs in six innings while with Texas.
Starlin Castro has five hits in the last three games, including a two-run homer Tuesday.