Monday's matchup at Wrigley Field features one team enduring its longest losing streak in 15 seasons and one that hasn't scored in 26 innings.
Chicago (15-32) is on its longest slide since the 1997 team began 0-14. The Cubs were swept over the weekend in Pittsburgh, with six defeats during their skid coming by one run before a 10-4 loss Sunday.
"Not only to not get results, but to feel like you are getting embarrassed, it is frustrating," catcher Koyie Hill said.
San Diego (17-32) hasn't been much better lately, dropping six of seven and going without a run since Jesus Guzman's first-inning sacrifice fly in a 6-1 loss to the New York Mets on Friday. The Padres were shut out Saturday and Sunday to close that four-game set.
If there's hope for the Cubs on Monday, it's their success over the years against San Diego's Jeff Suppan (2-3, 4.21 ERA), whose 11 losses to Chicago are his most against any team.
Suppan has gone 0-6 with a 6.23 ERA in his last nine starts against the Cubs, and he's 1-9 with a 5.38 ERA in his last 15 road starts overall.
The right-hander has gone 0-3 with a 6.32 ERA in his last three outings. Suppan gave up five runs over 4 2-3 innings in a 6-3 loss at St. Louis on Wednesday.
The Cubs, however, have scored four runs over 37 2-3 innings against starting pitchers in their last six games. Erik Bedard threw six scoreless innings against them Sunday.
"We didn't score, again, off the starter, so that magnifies everything,'' manager Dale Sveum said.
The Padres hope Carlos Quentin and Cameron Maybin are both in the lineup Monday. Quentin, out since right knee surgery in mid-March, could join the team in Chicago for his San Diego debut. The outfielder has completed two rehab stints.
"There's a chance you could see him in the field," manager Bud Black told the Padres' official website.
Maybin has struggled with a .216 average, but the injury-plagued Padres would welcome his return. He sat out a 2-0 loss Sunday with a right wrist sprain.
"It feels better," Maybin said. "It was a little more swollen (Saturday). I think it could have been from swinging."
San Diego, 3-15 against left-handed starters, will face Travis Wood (0-1, 3.86) in his third start for Chicago. Wood yielded two runs over 5 2-3 innings in a 2-1 loss at Houston on Tuesday as he took the place of the demoted Chris Volstad in the rotation.
Wood has gone 0-0 with a 2.63 ERA in two career starts against the Padres.
Only the Pirates have scored fewer runs among NL teams than the Cubs (161) and Padres (151). San Diego is last in the majors with 18 homers.
These teams split six 2011 matchups.