The Orioles could be in position to even the series based on how Jason Hammel has fared on the road.
Already 3-0 through three road outings, Hammel will try to help end the Mariners' season-high win streak at three Tuesday night.
Baltimore (15-11) captured the final eight 2012 meetings between these clubs before Seattle won 6-2 in Monday's contest.
Now Hammel (3-1, 3.82 ERA) looks to remain perfect on the road for the Orioles after posting a 2.50 ERA in his first three starts away from home. He allowed two unearned runs over six innings Thursday in a 10-2 win at Oakland.
Manager Buck Showalter likes the composure Hammel is displaying.
"At this stage in his career, when he gets mad or frustrated he's able to channel it in the right direction," Showalter said.
Hammel is 1-1 with a 3.00 ERA in three career starts against the Mariners, losing his lone outing against them last season for Baltimore's most recent defeat in this series before Monday.
The right-hander has never faced Michael Saunders, who was activated by Seattle (12-16) on Monday and helped key the victory with a homer and two RBIs after being on the disabled list with a sprained right shoulder. Jason Bay added three hits, improving to 7 for 14 on this homestand.
Mariners second baseman Robert Andino played his first game against the Orioles, with whom he spent his previous four seasons. Andino likes what he is seeing from his current team, with the Mariners winning four of five.
"We've all got a good momentum,'' Andino said. "Everybody's pitching in, doing their part, passing the baton and we've got a good flow going on right now."
Matt Wieter's two-run homer in the fourth inning was all the Orioles mustered.
Former Seattle outfielder Adam Jones' hitting streak ended at nine games Monday after he went 0 for 4 for Baltimore. Jones batted .342 with seven RBIs during his run.
Nate McLouth, meanwhile, got the night off after totaling seven hits over his two previous games.
The Orioles will get their first look at Mariners rookie starter Brandon Maurer (2-3, 5.61), who has turned things around dramatically after a rough start to his big-league career. He went 0-2 with a 16.20 ERA in his first two outings before going 2-1 with a 1.89 ERA in his next three.
The latest evidence of that progress came Thursday when the right-hander struck out six over 6 1-3 innings in a 6-0 home win over the Angels.
"I'm getting more comfortable," Maurer told the Mariners' official website. "Just taking deep breaths, trying to stay through with my legs and deliver a pitch."
Seattle hopes more fans will show up after an attendance of 9,818 on Monday - the smallest in the 14-year history of Safeco Field.