The same can't be said of the San Francisco Giants.
Davis looks to continue tormenting NL pitchers as the Orioles go for their longest interleague winning streak in franchise history Saturday against the Giants.
Baltimore (64-51) is batting .289 with 18 homers while going 8-4 during interleague play this year, and Davis has made major contributions to that success.
The first baseman leads the majors with a .477 average in interleague games, adding five homers, 11 RBIs and 14 runs. Overall, his 41 homers are the most in baseball, while his 108 RBIs tie him for the lead with Detroit's Miguel Cabrera.
Davis came through in the clutch for the Orioles on Friday, connecting for a two-out, two-run double in the 10th inning of a 5-2 win at San Francisco (51-64). They have won five straight against the senior circuit, matching team-best runs from 1999, 2009 and 2012.
"Chris made a lot of big plays," manager Buck Showalter said. "He's capable out there. A lot of good things happened."
That's certainly been the case lately, as Davis has plated six runs while going 4 for 11 (.364) with two doubles and one homer as Baltimore has won the first three on its eight-game road trip.
Manny Machado, who had a pair of doubles and runs Friday, is 5 for 14 with four runs over that stretch. The third baseman owns a .385 average in 12 interleague games.
Wei-Yin Chen (6-4, 2.95) is scheduled to face the Giants for the first time and will attempt to rebound from his first loss since returning from the disabled list in July.
The left-hander went 3-0 with a 2.57 ERA in four games after missing nearly two months with a strained right oblique. He looked capable of extending his winning streak Sunday, allowing one run in six innings before surrendering two in the seventh and getting charged with a 3-2 loss to Seattle.
Chen has found success against the NL, winning three of his last four starts behind a 2.59 ERA. He was superb in his most recent outing April 20, limiting the Los Angeles Dodgers to one run and three hits in six innings of a 6-1 victory.
Unlike Davis and the Orioles, the Giants are struggling in interleague play at 3-9 while batting .226.
Chad Gaudin (5-2, 2.56) is expected to take the mound for his first start against the Orioles since Aug. 21, 2003, when he was a rookie with Tampa Bay. The journeyman right-hander has faced them 10 times since as a reliever, most recently with the New York Yankees in 2010.
He enters this meeting as one of the Giants' most effective starters since being moved into the rotation June 1, going 5-1 with a 2.83 ERA in 10 starts while holding opponents to a .215 batting average.
"He's just been so consistent, both in the 'pen and starting," manager Bruce Bochy told the team's official website. "He's so valuable on this ballclub. We needed a starter and he's stepped in and he's thrown the ball as well as anybody."
That's certainly been the case while the Giants have won Gaudin's last two starts, as he's allowed two runs and struck out 13 in 13 1-3 innings.
Davis is 1 for 5 versus Gaudin, but all those matchups came in 2009.
San Francisco is scuffling at the plate with a .195 average and eight runs scored while dropping three of four. Buster Posey has been emblematic of those woes, going 1 for 8 his last three games and hitting .182 over his last 17.