They'll also be counting on Jose Fernandez to provide yet another solid outing as two of the hottest pitchers in baseball oppose each other Tuesday night at Coors Field.
Miami (36-61) had gone 37 innings without a run - the majors' longest such streak in 28 years - before Giancarlo Stanton's RBI double in the first inning of Monday's 3-1 win over Colorado (48-52) ended the drought, helping halt a four-game skid.
Ed Lucas added a homer for the Marlins, who had scored a total of seven runs while dropping their previous six road games.
"You know it's going to happen eventually,'' Lucas said. "It was important for us to do it early and get that monkey off our back. You could sense the relief in the dugout.''
Miami's offense could get another boost from Christian Yelich and Jake Marisnick, outfielders who are ranked among baseball's top prospects and will be called up from Double-A prior to Tuesday's contest.
Both figure to be in the lineup to make their debuts against Chacin (9-4, 3.50 ERA), who has rebounded from a rough stretch to become one of the league's best pitchers of late.
After going 0-3 with a 6.43 ERA in seven starts from May 5-June 6, Chacin went 6-1 with a 1.94 ERA over his next seven outings to end the first half on a tear.
He allowed one run and struck out six in six innings of a 3-1 win over the Los Angeles Dodgers on July 14.
"Before I was just trying to just throw it hard,'' Chacin said. "Now, I'm just trying to make my pitch, get them to hit it and get themselves out."
The right-hander hasn't had much success versus the Marlins, though, going 0-3 with a 9.00 ERA in two starts and a pair of relief appearances.
Fernandez (5-5, 2.75 ERA) has posted a 1.72 ERA over his last eight starts, allowing one run and four hits through six innings of Miami's 2-1, 10-inning win over Washington on July 13.
He also struck out two of the three hitters he faced in last Tuesday's All-Star Game.
Fernandez has allowed fewer than two runs in half of his 18 starts, and opponents are hitting just .196 against him. The rookie right-hander, who turns 21 on July 31, has tossed 104 2-3 innings, but manager Mike Redmond said he won't use Fernandez any differently despite an innings limit of 150-170.
"We're going to use him the way we have the whole year until those innings dry up," Redmond told the team's official website.
Fernandez has thrown at least six innings in seven of his last eight starts.
"We're not going to pull him out early because we want to save his innings," Redmond said. "In every one of his starts, we're going to try to win."
Colorado's offense may be in for another tough night after scoring fewer than two runs for the eighth time in its last 14 contests. Troy Tulowitzki had two hits for the third time in his last four games, homering in the fourth.
"We got some hits, but we couldn't string anything together,'' manager Walt Weiss said. "You score one run, you're not going to win many games.''