Greinke will seek to improve to 16-0 all-time at Miller Park and earn his fifth straight victory overall when he faces the resurgent Miami Marlins, losers of eight in a row against Milwaukee.
Greinke (9-2, 2.82 ERA) hasn't pitched at home since June 6, when he struck out a season-high 12 during an 8-0 victory over the Chicago Cubs. He's won each of his last two starts on the road, including an 8-4 victory over Cincinnati on Wednesday in which he gave up two runs over six innings.
Greinke, who has a 1.67 ERA over his last six starts, might have some extra motivation in his return home after being left off the NL's All-Star roster that was named Sunday.
"There's some starters having some great years," manager Ron Roenicke told the Brewers' official website before Sunday's 2-1 victory over Arizona. "But I would expect (Greinke) to make it. ... He's pitching like an All-Star."
Greinke always seems to pitch like an All-Star at Miller Park. The right-hander is 15-0 with a 2.50 ERA in 21 home starts since joining the Brewers (36-42), and will now try to become the third pitcher since 1900 to win his first 16 home decisions for one club. Johnny Allen pulled off that feat for the New York Yankees from 1932-33, and LaMarr Hoyt matched it from 1980-82 for the Chicago White Sox.
Greinke wasn't at his best when he faced the Marlins (38-40) at home Sept. 24, giving up four runs, nine hits and five walks over five innings. He's 2-0 with a 4.50 ERA in three career starts against Miami.
In this one, Greinke will face a club that's won four straight for its longest streak since opening May with a season-high seven consecutive victories.
Miami has batted .301 and posted a 2.25 ERA while winning its last four games by a 19-9 margin. Giancarlo Stanton hit his fifth home run in 10 games during Sunday's 5-2 victory over Philadelphia, and Hanley Ramirez belted his first since June 3.
"We've been waiting for Hanley's big day," manager Ozzie Guillen said.
Stanton and Ramirez will next try to help Carlos Zambrano (4-6, 3.71) end a three-game losing streak. He has a 7.88 ERA over that four-start stretch but was charged with five unearned runs - all in the first inning - in a 5-2 loss to St. Louis on Tuesday. Zambrano committed one of Miami's two errors during the opening frame when his throw to second base went into center field.
Thanks to his time with the Chicago Cubs, the right-hander has a bevy of experience against the Brewers, going 13-10 with a 3.84 ERA in 31 starts. He's lost his last two matchups against Milwaukee.
All of the Marlins' current surge - which has followed a miserable 3-17 stretch - has come at home. They've lost four straight on the road.