The two-time NL Cy Young Award winner looks to avoid losing a fourth consecutive start by trying to continue his dominance over the Padres on Tuesday night.
Lincecum (2-6, 5.82 ERA) is 0-4 with a 5.88 ERA in six starts since giving up an unearned run and three hits in eight innings of a 2-1 home victory over San Diego on April 28. The right-hander allowed two runs but matched a season high with five walks in seven innings of a 4-1 loss to Arizona on Wednesday.
"It was big on a personal level because I haven't been going deep into games,'' Lincecum said. "Outside of the walks, I thought it was better altogether."
He's in the midst of his worst stretch since dropping five straight starts Aug. 5-27, 2010.
"We're so behind Timmy,'' manager Bruce Bochy said. "He's the guy we want out there."
That will certainly be the case Tuesday night.
Lincecum, 10-4 with a 1.84 ERA in 19 starts against the Padres, has allowed four runs - two earned - in 29 innings while winning each of his last four against them. He is 3-0 with a 1.33 ERA in his last four starts at Petco Park.
Lincecum looks to lead San Francisco (31-24) to a fifth consecutive victory after it outscored the hapless Chicago Cubs 11-6 during a four-game home sweep. Brandon Crawford had two RBIs and Ryan Vogelsong pitched seven strong innings as the Giants won for the seventh time in eight games, 3-2 on Monday.
San Francisco starters have gone seven straight games of at least seven innings while allowing two or fewer runs. It's the longest such stretch for the club since a nine-game run July 1-10, 1988.
Melky Cabrera went 0 for 4 on Monday, but is still batting .432 in his last 18 games. He's hit .357 (10 for 28) with six doubles in his last seven versus San Diego.
The Giants have won 13 of 17 overall against the Padres (18-37) and 10 of 14 at Petco. San Francisco took two of three at home from San Diego in April as the teams combined for 16 runs.
Losers in 11 of 13 overall, the Padres scored 23 runs in their previous four games before totaling two in back-to-back losses to Arizona. The Padres were held to six hits in a 6-0 loss to the Diamondbacks on Sunday.
Carlos Quentin had the day off, but is 9 for 19 with three homers and seven RBIs in five games since making his 2012 debut May 28 after recovering from knee surgery.
It's uncertain how much time outfielder Will Venable could miss after suffering a strained oblique Sunday.
"We will see how it sets up," manager Bud Black told the Padres' official website. "Some (oblique strains) are nasty, some are not. Some go away quickly."
Scheduled starter Anthony Bass (2-5, 4.00) has allowed 11 runs and seven walks in 10 innings while going 0-1 in his last two starts. He gave up five and walked four in 4 2-3 innings of an 8-6 loss at Chicago on Wednesday.
The right-hander yielded two runs and struck out eight in eight innings in the loss to Lincecum on April 28.