Marquis goes for a ninth consecutive victory and fourth in a row over the Los Angeles Dodgers, who visit Petco Park for the first time since April's bench-clearing brawl Thursday night.
After giving up a season-high seven runs in 4 2-3 innings in a 7-1 loss to Milwaukee on April 22, Marquis (9-2, 3.63 ERA) has gone 8-0 with a 3.25 ERA over a 10-start stretch. The veteran right-hander, who's allowed at least four base on balls in all but two of those outings, has surrendered 47 walks on the season.
Marquis yielded three runs, three hits and four walks in 6 2-3 innings in Saturday's 6-4 victory over Arizona. He has a chance to become the first Padres pitcher to win nine consecutive decisions since Kevin Brown won 11 straight May 26-Aug. 5, 1998.
Marquis now turns his attention to the Dodgers (30-40), against whom he's gone 3-0 with a 2.52 ERA over four outings since the start of last year. He gave up two runs, three hits and two walks in 6 1-3 innings in a 6-2 victory at Dodger Stadium on June 5.
"Marquis is a tough matchup, he's given us trouble," Dodgers manager Don Mattingly told MLB's official website. "He seems like he pitches good every time. He's a guy that keeps the ball down. He can run the ball at you and break the ball off the plate to the other side. He's tough."
Los Angeles is set to make its first trip back to San Diego since drama unfolded April 11. After getting hit by a pitch, Padres outfielder Carlos Quentin charged and collided with Dodgers pitcher Zack Greinke, who suffered a broken collarbone.
These teams have played two series since, with the Padres (36-36) taking four of six at Chavez Ravine.
Yasiel Puig, who went a combined 5 for 8 with two homers and five RBIs in leading the Dodgers to two wins over San Diego in his first taste of big league action June 3-4, has yet to cool off.
Batting .474 in 15 games since getting called up from Double-A Chattanooga, Puig hit his fifth homer as Los Angeles cruised to a 6-0 road win over the New York Yankees in the back end of Wednesday's doubleheader. The Dodgers dropped the first game 6-4.
Hanley Ramirez also came up big on the day, going 6 for 8 with a homer and four RBIs.
"Hanley, for me, I've said it since he came over. I think he's one of the best hitters in the game," Mattingly said. "The way Yasiel's swinging the bat, if Adrian (Gonzalez) continues to swing the bat the way he's capable of, that's a pretty potent trio of guys."
Gonzalez, who spent five years with San Diego from 2006-10, is hitting .309 with a team-leading 45 RBIs.
The Padres followed up a season-high seven-game winning streak with back-to-back losses, falling 4-2 at San Francisco on Wednesday. San Diego found itself in another on-field altercation after Madison Bumgarner threw a pitch behind Jesus Guzman's back, prompting both benches to clear.
Guzman, who celebrated after hitting a go-ahead pinch-hit two-run homer in the eighth inning of Tuesday's 5-4 defeat, went deep again Wednesday.
San Diego placed shortstop Everth Cabrera (strained left hamstring) on the disabled list Wednesday and could also be without Quentin again. He's missed the last five games with a shoulder injury.
The Padres will try to regroup against Dodgers scheduled starter Stephen Fife (1-2, 3.74). The right-hander's lone win came June 3, when he gave up a run in 5 1-3 innings of a 2-1 victory over San Diego.