The right-hander looks to avoid a career-high fourth consecutive home loss and help the Brewers hand the Cubs a 10th straight defeat at Miller Park on Wednesday night.
Gallardo (6-6, 4.09 ERA) has not allowed an earned run in 21 innings while giving up 12 hits to go 2-0 in his last three starts - all on the road. He was charged with three unearned runs and five hits in seven innings of a 7-4, 10-inning loss at Houston on Thursday.
"I know for a fact the guys behind me don't want to make errors," he said. "They want to get every out they can. That is just how it is. As a pitcher, you have to move past it, whether it's an error or a misplayed ball. You have to focus on the next guy."
Gallardo's focus has generally been very good when facing the Cubs (31-44), going 7-2 with a 2.95 ERA in 14 starts against them. Chicago has won only once in seven matchups with Gallardo at Miller Park as he's gone 4-1 with a 2.66 ERA.
However, the Brewers have lost his past four starts there and he's lost the last three while posting a 6.75 ERA. It's his longest home losing streak since dropping three in a row in 2009.
Gallardo, though, hasn't pitched at Miller Park in three weeks, and the Brewers (32-43) have won six of seven at home after a 9-3 victory over Chicago on Tuesday. Rickie Weeks hit two homers and had four RBIs as Milwaukee used a five-run fifth inning to erase a two-run deficit.
Weeks is batting .439 with five homers and nine RBIs in his last 14 games to raise his average from .182 to .230.
"It feels good," he said. "It's just one of those things where you keep working on things, and just go out there and play ball. There's no satisfaction. There's no big answer. Just go out there and play ball like I've been doing."
Teammate Jean Segura, batting .334, collected his NL-leading 100th hit Tuesday with an RBI double. He's hitting .368 in five games against the Cubs in 2013.
Fellow shortstop Starlin Castro should be back in Chicago's lineup after his NL-leading streak of 269 consecutive games played ended Tuesday. He's batting .129 with no homers and three RBIs in his last 23 games.
Castro has hit .156 and Darwin Barney .107 during the Cubs' nine-game losing streak at Milwaukee. They've been outscored 52-22 in that span and have dropped 19 of 21 there.
"We lost nine straight?" said Anthony Rizzo, batting .308 in seven career games at Miller Park. "(I had) no idea. I don't know if anyone in this clubhouse knows that."
Scheduled starter Scott Feldman (6-6, 3.39) dropped to 0-4 with a 6.65 ERA this season against NL Central opponents after he allowed five runs and four walks in 5 1-3 innings of a 6-1 loss at St. Louis on Thursday.
The right-hander yielded three unearned runs and three hits in five innings of a 4-2 loss at Milwaukee on April 21.
Nate Schierholtz is 6 for 12 with two homers and six RBIs in the last three games for the Cubs, who have dropped six of nine.