Facing Jered Weaver isn't likely to help, either.
The A's attempt to beat Weaver for just the second time in three years Wednesday in the series finale in Anaheim.
Oakland (94-64) has already clinched back-to-back AL West titles, but is still in the running for home-field advantage in the postseason. The A's trail AL East champion Boston by one game with four to play.
Falling short of the league's best record could cause Oakland to lament its performances against Los Angeles in the final month of the regular season.
The A's have dropped three of the past five meetings, including Tuesday's 3-0 defeat in which they were held to four singles.
Offense may be at a premium again with the Angels (77-80) sending Weaver (10-8, 3.36 ERA) to the mound.
The right-hander is 7-1 with a 0.84 ERA over his last 10 starts against Oakland, throwing 22 2-3 scoreless innings while winning his past three meetings.
He was stellar again in the most recent matchup July 19, leaving with two outs in the seventh of a 4-1 home victory.
Weaver, though, was scratched from his latest scheduled start Friday due to tightness in his forearm, but he's planning to conclude the season in strong fashion.
"I didn't want people to think that I was just packing it in because it's the end of the season," Weaver told the team's official website. "We still have a job to do. If I was feeling healthy, I'd be out there.
"I'm excited to go out there and make that last start on Wednesday."
The A's surely don't share that sentiment since they've managed only 10 hits off him while striking out 26 times over the past three matchups.
That likely means Oakland will need another strong performance from Dan Straily (10-7, 4.08), who is 4-0 with a 2.15 ERA over his last five starts. That impressive stretch came after he went 0-5 with a 5.20 ERA in seven outings, starting with a 2-0 defeat at Angel Stadium on July 20.
The rookie right-hander, though, did his part by yielding two runs in seven innings while his offense was held to three hits.
Still, he's 0-2 with a 7.31 ERA in three starts versus Los Angeles this year.
Straily's recent success continued Thursday, when he allowed two earned runs in 5 2-3 innings of an 8-6 home win over Minnesota.
Oakland's Jed Lowrie had two hits Tuesday and is 12 for 31 (.387) with three homers, seven RBIs and eight runs over the past seven games.
He's 11 for 23 (.478) with two homers while driving in eight runs and scoring six in his past seven meetings with the Angels.
Los Angeles' Howie Kendrick is batting .353 with 12 RBIs in 16 games versus Oakland in 2013. He's homered in both games of this series after failing to go deep in his previous 30, and his five RBIs match his total from his previous 16 contests.