The AL Central-leading Tigers look to continue that home success by handing the Angels a fourth straight defeat Tuesday night.
Detroit (42-32) has been outscored 34-9 while dropping six straight to the Angels, all at Anaheim. The Tigers were held to four runs in a three-game series there April 19-21.
However, Detroit has averaged 5.0 runs while winning 13 of 19 at home against the Angels (33-43), including six of eight.
The Tigers are 4-3 on a 10-day homestand and looking for a third consecutive victory after totaling 27 runs to take three of four from AL East-leading Boston. They were the recipient of a questionable non-catch call on a fly ball to Boston outfielder Daniel Nava that opened the door for a three-run eighth inning in Sunday's 7-5 victory.
"Sometimes it's your day, sometimes it isn't," Tigers manager Jim Leyland said.
Detroit center fielder Austin Jackson went 6 for 11 in the series. He's hitting .457 (16 for 35) in nine games since he returned from missing a little more than a month with a strained right hamstring.
Jackson, though, is 2 for 39 (.051) in his last nine games against Los Angeles.
Teammate Miguel Cabrera has hit .486 (17 for 35) with two homers and six RBIs in his last nine games overall. He went 6 for 11 against Los Angeles in April and is 5 for 15 with two doubles versus scheduled starter C.J. Wilson (6-5, 3.61 ERA).
The left-hander tries to end his recent road struggles while looking for a third consecutive winning start. He allowed two runs and seven hits in 14 innings over the last two - both at home - following a three-game stretch where he went 0-2 with a 6.35 ERA.
Wilson gave up two hits in seven innings of a 1-0 win over Seattle on Wednesday.
"You never want to lose 1-0; you always want to win," he said. "I've lost a lot of those games this year already."
Wilson is 0-3 with a 5.56 ERA in his last four road outings and 0-2 with an 8.20 ERA in three starts at Comerica Park, including the postseason. His last start against the Tigers came at home April 21, when he gave up three runs and walked four in six innings of a 4-3, 13-inning win.
Albert Pujols went 1 for 12 while the Angels were swept at home by Pittsburgh over the weekend, but he's batting .548 (23 for 42) with five homers and nine RBIs in 11 regular-season games at Detroit.
Angels star Mike Trout went 5 for 15 against the Tigers in April and hit a grand slam off scheduled starter Rick Porcello (4-4, 4.74) during a 10-0 win April 20.
Porcello allowed nine runs and nine hits while facing 11 batters in two-thirds of an inning to fall to 3-3 with a 7.68 ERA in eighth starts against Los Angeles.
Since that outing, Porcello is 4-2 with a 3.43 ERA in 10 starts. However, he gave up six runs in six innings of a 13-3 loss to Baltimore on Wednesday.