A-Rod leaves Red Sox game with a tight right calf
Vernon Wells pinch hit for Rodriguez in the fifth inning.
Rodriguez was 1 for 2 with a single in the game, which is the Yankees' last in Boston this year.
New York entered the night trailing AL wild-card leaders Oakland and Texas by 2 1/2 games.
Rodriguez was on the disabled list until Aug. 5 recovering from left hip surgery. He is batting .280 with six homers in 35 games.