Maclin hurt his groin early against Jacksonville on Nov. 6 and has not played since. His absence has coincided with a pronounced drop in production by the offense.
Outside linebacker Dee Ford, who has 10 sacks this season, has also been ruled out after hurting his hamstring in last week's loss to Tampa Bay. Defensive tackle Jaye Howard is out with a hip flexor.
The Chiefs hope to get top cornerback Marcus Peters back from a hip pointer. He was questionable on the final injury report Friday, along with linebacker Derrick Johnson, defensive tackle Dontari Poe, defensive end Kendall Reyes and cornerback Steven Nelson.