Who will start, Lloris or Friedel?
Villas-Boas must decide whether to stick with Hugo Lloris or recall Brad Friedel in goal and Emmanuel Adebayor could make his first league start of the season at his former club.
Mousa Dembele (hip), Scott Parker (Achilles), Benoit Assou-Ekotto and Younes Kaboul (both knee) are unavailable.
Manchester City trio Joleon Lescott, Maicon and David Silva are hoping to return to action on Sunday.
Defenders Lescott (back) and Maicon (foot) - the Brazilian was an unused substitute in midweek - and playmaker Silva (hamstring) are all back in training after spells on the sidelines.
Right-back Micah Richards (knee) and midfielders James Milner and Jack Rodwell (both hamstring) remain on the injury list.
Manchester City: Hart, Pantilimon, Wright, Zabaleta, Maicon, Kompany, Lescott, Nastasic, K Toure, Clichy, Kolarov, Nasri, Y Toure, Barry, Garcia, Sinclair, Silva, Aguero, Dzeko, Balotelli, Tevez.
Tottenham: Friedel, Lloris, Cudicini, Gomes, Naughton, Walker, Caulker, Gallas, Dawson, Vertonghen, Livermore, Parrett, Huddlestone, Mason, Carroll, Sandro, Sigurdsson, Lennon, Townsend, Bale, Falque, Dempsey, Obika, Defoe, Adebayor.