Pumas beat Cruz Azul 1-0 in CONCACAF
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Barrera scored in the 23rd minute. The victory was Pumas' first over Cruz Azul after eight straight losses against Cruz Azul at Pumas' home stadium.
The second leg of the total-goals series is April 6 at Cruz Azul.
On Tuesday in the other first-leg semifinal, Mexican clubs Toluca and Pachuca drew 1-1.