Valencia begins Pizzi era with win
Argentina-born Pizzi's countryman Pablo Piatti drilled home the opener just before half-time and the influential Sofiane Feghouli sealed the win midway through the second half with a neat finish.
Real Valladolid and Real Betis shared the spoils in an exciting albeit goalless draw at the Jose Zorilla stadium, a result that does little to help either team's precarious situation in the Primera Division.
Los Blanquivioletas move one point away from the drop zone but could find themselves back in it on Sunday if Osasuna beat Espanyol, while Betis remain rooted to the bottom of the table, five points behind Valladolid.
On the plus side for the Andalusians, Juan Carlos Garrido finally earned his first point since taking over as coach last month.
Despite the lack of goals, this was an open game in which both teams showed ambition going forward but were unable to put the ball in the net.