Steven Stamkos had a goal and two assists in regulation for the Lighting (4-0-0), putting them ahead 4-3 at the 7:35 mark of the third period before Bobby Butler tied it for the Panthers (2-2-1) with 58 seconds remaining -- his second goal of the game.
Ryan Malone and Martin St. Louis scored in the first to give Tampa Bay a 2-0 lead at the end of the period. Erik Gudbranson and Dmitry Kulikov scored in the second to help the Panthers pull to 3-2 heading into the third.
J.T. Brown scored for the Lightning in the second.
Ben Bishop stopped 25 shots for the Lightning, while Jacob Markstrom made 29 saves for the Panthers.