Jackson, who had three hits, Pearce and Exposito homered in a four-run sixth inning off Toronto reliever Esmil Rogers. The home runs by Jackson and Pearce were back-to-back.
The Orioles also homered four times on Sunday against Philadelphia.
J.A. Happ started for Toronto and allowed Pearce's first homer -- a two-run shot -- in three innings.
Baltimore's Steve Johnson gave up two runs in two innings, and Jair Jurrjens allowed three runs and five hits in 2 2-3 innings.
The teams combined for 29 hits.
Alexi Casilla had three hits for the Orioles.
Rays 7, Twins 5
FORT MYERS (AP) -- Liam Hendriks worked out of a jam after left-fielder Josh Willingham lost a fly ball in the sun, but the Minnesota Twins still lost to the Tampa Bay Rays 7-5 Tuesday.
Hendriks, trying to win a spot in Minnesota's rotation, allowed two runs and four hits in three innings. He pitched three innings, giving up two runs off four hits while striking out three.
Rays pitcher Matt Moore struggled with his mechanics. He struck out two but gave up two hits and two walks in 2 2-3 innings.
Juan Sandoval, trying to make the big leagues with the Rays after losing sight in his right eye seven years ago, struck out one and earned the save, his second of spring training.
Dominican Republic 15, Phillies 2
CLEARWATER, Fla. (AP) -- Jose Reyes,
Hanley Ramirez and the Dominican Republic put on a relentless offensive display in their first exhibition game ahead of the World Baseball Classic, amassing 28 hits in a 15-2 romp over Cole Hamels and the Philadelphia Phillies.
Reyes led off the game with a single and the Dominican Republic team never let up, roughing up Hamels for 12 hits and eight runs in 2 2-3 innings, his third start of spring training.
Reyes, Robinson Cano and Ramirez each homered. Ramirez and Miguel Tejada had four hits apiece for the Dominican team. Cano had three hits and three RBIs and
Edwin Encarnacion also had three hits.
Dominican right-hander Samuel Deduno allowed one run on three hits. Deduno struck out three and didn't walk a batter.
Laynce Nix hit his first home run of the spring for the Phillies.