La Salle 79, Lafayette 53
Duren also chipped in six assists and four steals.
The Explorers shot 49.2 percent (30 of 61) from the floor and held the Leopards to just a 36 percent (18 of 50) mark. They also outrebounded Lafayette 44-27 in the game.
From 3-point range, La Salle was 9-for-16 compared to a 3-for-10 performance by Lafayette.
La Salle built a 23-point halftime advantage and outscored Lafayette 36-33 in the second half to seal it.
Jim Mower scored 12 points and Dan Trist added 10 for the Leopards.